this post was submitted on 15 Oct 2023
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Skeletons from 1918 flu dispel myth that young, healthy adults were more vulnerable to the virus (www.livescience.com)
submitted 11 months ago by throws_lemy@lemmy.nz to c/science@beehaw.org
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[–] Darukhnarn@feddit.de 1 points 11 months ago

The phylogenetic results, combined with these other lines of evidence, suggest that the high mortality in 1918 among adults aged ∼20 to ∼40 y may have been due primarily to their childhood exposure to a doubly heterosubtypic putative H3N8 virus, which we estimate circulated from ∼1889–1900. All other age groups (except immunologically naive infants) were likely partially protected by childhood exposure to N1 and/or H1-related antigens.

The Spanish flu apparently had the N1 complex present, to which the 20-40y population wasn’t exposed. At least that’s my limited understanding after skimming the paper.