It's nice that major news outlets are saying what we nerds have been screaming for the past two decades. Microsoft only shares a small portion of the blame for the recent outage (they could have built their OS better so software vendors don't feel the need to use kernel modules, but the rest is on CrowdStrike) but we are too depenent on them.
If my American university has a system in place for students that don't own Windows, I would not be surprised if yours has a better one :)
LibreOffice has opened every DOC(X) the school has sent me, albeit imperfectly, and all assignments are turned in as PDFs, which I usually make using Markdown and LaTeX. I have had to use Office 365 for collaboration, but only about twice a year, and that runs very smoothly in Firefox. On one occasion I tried to collaborate with CryptPad, but it didn't work as well as I hoped.
Most computer labs at my uni run Windows 10, rarely 11, but a lot of the science labs run Linux.
The most frustrating thing has been the lockdown browser used for some exams. My university library has computers I can borrow for exams, but yours might not, and they detect VMs, so you might have to dual boot for that.
"Move Along Home" would work so much better as a Doctor Who episode. Has a kind of absurdity that is perfect for Who, but stands out in a bad way in Trek.
I don't have much PC building experience, but these specs seem sufficient. Only comment is that you might need to use a distro with a new-ish kernel and graphics stack, given the very recent CPU and GPU. So not Debian stable, but Fedora, Ubuntu, or any rolling release distro will be fine.
Normal, plug and play mice last a long time, with or without firmware updates, which are typically free. I guarantee that nobody will buy this mouse, and if it does release it will stop receiving updates within six months.
Handbrake will probably still work if you compile it from source, but it seems like upstream isn't paying much attention to libdvdcss support.
The version in Debian's repo still works for me, anyway.
OC please steal
If you haven't set up this laptop yet, then I'd suggest installing a server-oriented distro like Debian, AlmaLinux, or Ubuntu Server. Those have minimal install options that come without a desktop environment installed, as most servers do not need one. If you'd like to make the install harder for yourself, this might be a good excuse to give Arch Linux or Gentoo a try, as those have the option of a fully manual install. If you'd like, you can install a desktop environment afterwards using the package manager.
If you already have a Linux with a graphical desktop installed, you can configure the system not to automatically start it with sudo systemctl set-default multi-user.target. (Do not do this on your main device!) You can re-enable it with sudo systemctl set-default graphical.target.
Regardless, you can then start a graphical session using startx, or whatever command is more appropriate for your desktop environment (gnome-session to start GNOME on Wayland, startplasma-wayland to start KDE Plasma), or by sudo systemctl starting your login screen manager (sddm, gdm, lightdm, etc).
I'm currently on the RHCSA path myself, and I can tell you that the courses are not worth the thousands that Red Hat charges. There are plenty of unofficial video courses on YouTube and Udemy and study guides and practice tests on GitHub that are free or cheap, and other resources for every individual study topic, which will be good enough.
However, though I can't speak from experience, it seems like the cert itself will look good enough on a resume to justify the investment of $500 and a month of studying.
Assuming you mean the Beelink S12 (which is the first thing that comes up in a search for "n100 mini pc"), that's quite similar to my own computer specs, which can run just about any distro, with enough resources to spare for a VM or two. I don't think it's necessary to go really lightweight or pick something special. If there's a distro you're already familiar with and know you can do all of those things on, install that.
If you like Garuda, you could always try a different Arch spin which is lighter out of the box, like CachyOS or EndeavourOS.
"I can't stop the heterocyclic declination!" (TNG: "Samaritan Snare")