You can even get an item in Elden Ring called the Twiggy Cracked Tear about a third of the way through that lets your Physick flask grant the same effects as a Sacrificial Twig for 3 minutes. Once you get that, the stress of losing Runes can be greatly diminished.
Simply drink it prior to crossing a fog wall or at a difficult point on the path to Rune retrieval.
If that's not enough, and you're on PC, you can download a simple mod off Nexus which eliminates Rune loss on death entirely.
You can even get an item in Elden Ring called the Twiggy Cracked Tear about a third of the way through that lets your Physick flask grant the same effects as a Sacrificial Twig for 3 minutes. Once you get that, the stress of losing Runes can be greatly diminished.
Simply drink it prior to crossing a fog wall or at a difficult point on the path to Rune retrieval.
If that's not enough, and you're on PC, you can download a simple mod off Nexus which eliminates Rune loss on death entirely.