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How about we play, "Never have I ever"? (fedia.io)

submitted 2 months ago by bizarroland@fedia.io to c/asklemmy@lemmy.ml

286 comments fedilink hide all child comments

Here's the rules:

1: Post something you have never done that you think many people do. 2: Read the other posts, if you have done that thing, upvote it. If you have not done that thing, downvote it. 3: If you believe the person is lying, call them out on it in a reply. 4: If you are called out, give the full story. 4a: If you see a thread containing the full story, boost the person you think is right and truthful.

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[–] WeirdGoesPro@lemmy.dbzer0.com 1 points 2 months ago (1 children)

The tolerance isn’t totally mental, it just takes longer to build and recede than alcohol does.

To each their own though, not trying to pressure anybody.

[–] tetris11@lemmy.ml 2 points 2 months ago* (last edited 2 months ago) (2 children)

where does the tolerance come from though? With alcohol it's very clear that there's one organ doing the heavy lifting. With weed, I have no idea.

To each their own though, not trying to pressure anybody.

Of course! Likewise, I'm not trying to shame anyone for picking weed over beer. Each to their own

Edit: Apparently it's "CB1 receptor density" in your brain that handles the tolerance.

[–] deranger@sh.itjust.works 2 points 2 months ago

With alcohol it's very clear that there's one organ doing the heavy lifting

It’s not your liver, it’s your GABA receptors downregulating that gives you a tolerance. Your liver helps with the duration and hangover but the lower peak intoxication is mediated by the receptors. Likewise with cannabis, your THC receptors downregulate to give you a weed tolerance. It is also processed by the liver.

[–] WeirdGoesPro@lemmy.dbzer0.com 2 points 2 months ago

Indeed, a lot of drugs that are non toxic have tolerance created in the brain, while more toxic drugs have to get processed by the kidneys and liver, which is why the functioning of those organs contributes to tolerance.