this post was submitted on 20 Jun 2024
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lol this isn't about dry mouth. I already had dry mouth, which I manage with xylitol (lmk if they make any of those fruit things that can adhere to the side of your mouth like xylitol melts)
SSRIs cause dehydration. when I drink straight water on them, it sends me to the bathroom pretty frequently. I don't find Gatorade particularly more refreshing than water, but it tends to stay inside me after I drink it, when I'm on SSRIs. yes I've had my blood sugar checked
The water moving right through is probably a good sign someone is well hydrated! There can be total body water versus intravascular volume depletion scenarios, but not super likely unless someone is sick in other ways.
The xylitol itself may be contributing to GI water losses (it’s only about 50% absorbed through the gut, and osmotically draws water into/keeps water from being absorbed from the intestinal lumen). Depending on the SSRI, this could be exacerbated by bowel irritability that can present as diarrhea (sertraline is notorious for this).
Some folks also report more urination with intake of sugar alcohols like xylitol. I don’t have a mechanism of action for that, so take those reports with a grain of salt. (And also some glucose because sodium-glucose symport allows for water absorption without the need for an ATP pump.)
How do you boost intramuscular water retention? I get so dehydrated sometimes my brain burns and hurts. I need serious electrolytes like 1 to 3 body armours to replenish followed by 48oz water. Followed by hours to recalibrate my body from nausea and migraines. Urine can be clear but I can be so thirsty its unbearable. Literally feels like my brain is shrinking.
Those sound like two very different things. Typically your cells manage this just fine on their own with just plain water intake provided the kidneys are working fine. Time to attain equilibrium is also important. For example, dumping a bag of IV fluid into someone’s veins will help replenish the volume of fluid in their blood vessels quickly at the outset. But it will move to the other parts of the body (or get dumped by the kidneys if the intravascular volume is already adequate).
How well hydrated a person is before activity matters more for performance and recovery than we often recognize. Lots of studies of elite athletes and dehydration on performance and recovery. Also of these drinks have artificial sweeteners, that may be playing against you.
That sounds miserable. If better pre-activity hydration doesn’t solve the problem, you might want to speak to a care provider and make sure everything is ok with some tests.